The depth and coverage course · v0.6
Build a mental model, then inspect the evidence.
Twenty-four modules move from normal vessel biology through CAA, brain arteriolosclerosis, STRIVE-2, neuropathology, mixed disease, clinical outcomes, management evidence, the wider disease spectrum, and research design. Approximately 319 minutes for a first pass; every source marker opens the verification record.
Part I · Foundations
See the hidden system
Move from normal vessel biology to tissue injury without assigning disease ownership too early.
How to think about cSVD
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The field primer
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Vessel anatomy and the neurovascular unit
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Part II · Diseases and pathology
Understand the vessel-wall targets
Study CAA, arteriolosclerosis, mixed disease, and the limitations of neuropathology as a reference.
Brain arteriolosclerosis
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Cerebral amyloid angiopathy
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Neuropathology and reference standards
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Mixed pathology and cognitive attribution
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Part III · Imaging, diagnosis, and measurement
Use observations and criteria within scope
Learn STRIVE-2 phenotypes, diagnostic transportability, biomarkers, and validation ladders.
MRI phenotypes and STRIVE-2
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Diagnostic criteria and rating systems
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Diagnostic transportability
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Biomarkers and tools
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Diagnostic evidence profiles
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Part IV · Clinical spectrum and safety
Connect biology to human outcomes
Cover ischemic and hemorrhagic syndromes, cognition, covert disease, management evidence, and the wider cSVD spectrum.
Clinical spectrum and outcomes
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Management, prevention, and safety
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Monogenic and other small-vessel diseases
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Part V · Mechanisms and reasoning
Think in competing explanations
Work through live debates and cases while preserving mixed pathology and uncertainty.
Debates and open questions
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Worked reasoning cases
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Part VI · Evidence discipline
Learn to disagree productively
Expose contradictions, incomplete validation, and false replication before drawing conclusions.
Contradiction and falsification
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Evidence completeness
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Cohort lineage
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Part VII · Research and stewardship
Convert uncertainty into work
Prioritize gaps, design decisive studies, maintain the archive, and build a durable reading practice.
Research agenda
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From archive to research program
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Living update workflow
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Reading path to research fluency
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