The core course
Build a mental model before memorizing criteria.
Fifteen chapters move from anatomy and inference to criteria, biomarkers, live debates, diagnostic validation, contradiction, cohort independence, and research design. Approximately 148 minutes for a first pass; much longer if you follow the evidence.
Part I · Foundations
See the system
Learn how small-vessel injury becomes tissue damage and visible imaging without assigning disease ownership too early.
Part II · Diagnosis and measurement
Use criteria without worshipping them
Dissect what a terminology standard, diagnostic rule, biomarker, or evidence profile actually establishes.
Diagnostic criteria and rating systems
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Diagnostic transportability
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Biomarkers and tools
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Diagnostic evidence profiles
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Part III · Mechanisms and reasoning
Think in competing explanations
Work through live debates and cases while preserving mixed pathology and uncertainty.
Part IV · Evidence discipline
Learn to disagree productively
Expose contradictions, missing validation links, and false replication before drawing conclusions.
Contradiction and falsification
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Evidence completeness
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Cohort lineage
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Part V · Research and stewardship
Convert uncertainty into work
Prioritize gaps, design decisive studies, maintain the archive, and build a durable reading practice.
Research agenda
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From archive to research program
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Living update workflow
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Reading path to research fluency
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