A field guide built around calibrated inference
Learn small-vessel disease as a connected system.
Begin with vessels, tissue injury, and MRI footprints. Build toward CAA, brain arteriolosclerosis, Boston criteria, STRIVE-2, ARTS, mixed pathology, and the questions that could change the field.
Research and education only · 11 chapters · device-local progress · 202 linked evidence records
Vessel compartments and evidence relationships are connected—but never interchangeable.
Start with the course
A deliberate sequence, not a pile of links
The core course moves from first principles through disease models and diagnostic reasoning, then teaches you to challenge claims and design useful studies.
How to think about cSVD
Keep observation, phenotype, etiology, mechanism, and action separate.
From vessel wall to visible lesion
Build the anatomy, pathology, imaging, and mixed-disease model.
What criteria can and cannot do
Understand reference standards, spectrum effects, and transportability.
Use the atlas to reason
Move from a finding to an answerable question
Every route retains uncertainty and competing explanations. The database is subordinate to the reasoning task—not the other way around.
Name the phenotype
Use STRIVE language without converting a marker into an etiology.
02 · DIFFERENTIATECompare causes
Ask how location, morphology, context, and co-pathology change probabilities.
03 · AUDITInterrogate the claim
See what is supported, what is unproven, and what would decide it.
04 · INVESTIGATEFind the missing piece
Open research gaps already framed as testable designs.
Clinical boundary
This atlas teaches research-grade interpretation. It does not diagnose a patient, recommend treatment, or treat a radiology-report phrase as pathology-confirmed disease.